Your Best Shot by Ashley Koff, RD

Why You Need This Book Now

In a world full of quick fixes, influencers, and conflicting nutrition advice, Your Best Shot reframes weight health through a simple idea:

Your body isn’t the problem — it’s the environment it’s been trying to function in.

This book helps you:

• Understand your body as an ecosystem – every choice impacts its function
• Decode your weight-health hormone signals
• Optimize digestion, hydration, sleep, stress, and movement
• Build habits that work with your biology
• Learn pros and considerations of GLP-1 medications
• Create your own personalized “n=1 experiment” with practical tools you can start today

Written with clarity, compassion, and just the right amount of humor, Ashley Koff, RD, gives readers and practitioners a roadmap to better weight, better health, and a better relationship with their bodies.

Trusted by Leaders in Nutrition, Medicine, Science, and Wellness

Featuring praise from practitioners, experts and patients:

• Tieraona Low Dog, MD
• Frank Lipman, MD
• JJ Virgin, CNS
• Jeffrey Bland, PhD
• David Katz MD
• Emily Deschanel
• And many more…

Praise for Your Best Shot

Expert insights from the clinicians, industry leaders and businesses shaping the future of metabolic and weight health.

“Ashley is my go-to resource for health and nutrition answers because she is a walking encyclopedia of food knowledge, is incredibly informed about current policies and trends, and is always the first to know about future developments. But, more importantly, she explains things in a down-to-earth, accessible and fun way accompanied by easy, practical ways to incorporate her principles into your lifestyle so that better nutrition sticks. On a professional level, there is nobody I value more to consult with to ensure I’m imparting the most trustworthy knowledge to my readers. Her simple approach is refreshing and necessary in an era where the message is being muddied by 30-second gimmicks and sound bites that don’t make sense and don’t work.”
– Tess Masters, author of The Blender Girl, The Blender Girl
Smoothies, and The Perfect Blend.

“Ashley is one of the most insightful and trusted nutrition experts I know—there is no one I trust more to train practitioners and guide patients. Your Best Shot puts Ashley’s wisdom and knowledge into practice—it’s the weight management tool we have been waiting for.”
— Tieraona Low Dog, MD, ABOIM, Director, Integrative & Functional Medicine Fellowship, UC-I Susan Samueli Integrative Health Institute

“With growing interest in GLP-1 therapies, it’s more important than ever to have a guide you can trust. Your Best Shot is that guide: thorough, precise, compassionate. Ashley Koff, R,D gives you more than just protocols; she gives you the tools to understand your own body and choose what works best for you.”
— Frank Lipman, MD, New York Times bestselling author.

“Timely, engaging, and empowering. Overcoming the challenges of losing weight you don’t want, and finding the health you do, begins with understanding — and you will find that here in delightful abundance.”
— David L. Katz, MD, MPH, Past President, American College of Lifestyle Medicine; Founder, Diet ID.

“After decades of books that treat everyone the same, Your Best Shot emerges as a breakthrough. Ashley Koff, RD’s, new work recognizes that weight health is not one-size-fits-all: it’s about weight-health hormones, total nutrition, lifestyle choices, genetics, and more. The strategies are evidence-based, actionable, and rooted in real clinical practice. Our patients have benefited tremendously from this approach, and I am thrilled it is now available for everyone’s benefit.”
— Darshan Shah, MD, CEO & Founder, Next Health.

“This book is a powerful step by step guide to precise assessment and discovery, leading the reader to identify their next best step to optimal weight health, shot or not. Using clear explanations of the science, case studies, and fun ways to achieve real insights, the reader is able to create their own personalized plan for better weight and better health, and to continue to iterate on that plan with the tools provided. Your Best Shot is the best resource I have seen for understanding how to create your own personalized plan and next steps, understanding when and how to incorporate “the shot” or not.”
— Myles Spar, MD, Executive Medical Officer, WndrHlth.

“In Your Best Shot, Ashley Koff, RD, reframes the conversation with a refreshing blend of science and personalization. She helps us see GLP-1 medications for what they are: one potential tool, not the whole solution. Through science, patient stories, and her own journey, she shows that weight and metabolic health are built on a foundation of digestion, hydration, nutrition, and lifestyle. This book resonates deeply with my own philosophy of root-cause, whole-person care and is an essential guide for clinicians and patients alike who want lasting, not fleeting, results.”
— Deanna Minich, PhD, CNS, IFMCP, Author of Whole Detox and The Rainbow Diet.

“Your Best Shot is both groundbreaking and timeless. This is the weight-health system we’ve needed from an expert we all trust.”
— Jeffrey Egler, MD, Chief Medical Officer, Noom.

“In Your Best Shot, Ashley Koff, RD, draws on decades of clinical expertise and scientific insight to reframe the conversation about health and weight in the post-GLP-1 era. Blending practical tools for sustainable eating with clear, no-nonsense guidance that cuts through industry hype, she offers readers a trusted roadmap to understanding their weight, optimizing their wellness, and building a realistic foundation for lasting longevity.”
— Austin Perlmutter, MD, NYT bestselling author and Internal Medicine Physician.

“Your Best Shot isn’t another one-size-fits-all weight loss book—it’s the guide you’ve been waiting for. Ashley reminds you that the foundations to health matter, YOU matter, and the only plan that’s going to stick is the one built for your actual life that encourages personalization and adjustments whether you’re on a GLP-1 or not. I love how refreshing it is to see weight health explained this way—personal, doable, and real.
– Carrie Jones, ND, FABNE, MPH, MSCP

“In Your Best Shot, Ashley Koff RD offers a compassionate, science-based plan that reframes weight health as part of a whole-body ecosystem – shaped by nutrition, digestion, hormones, and lifestyle. This is the essential roadmap we need to support kids and families in building resilience and lasting weight health.
– Elisa Song, MD, Integrative Pediatrician and Bestselling Author of Healthy Kids, Happy Kids

“Your Best Shot offers a clear and empowering perspective on weight management, reminding us that true health is built on a foundation of nourishing, clean food, mindful living, and supporting the body’s natural detoxification processes. As an integrative medicine trained physician, I appreciate how this book places GLP-1 therapies in context—as one tool among many—while keeping the focus on holistic, sustainable approaches to overall health.”
– Aly Cohen, MD, Integrative Rheumatologist and bestselling author of DETOXIFY: The Everyday Toxins Harming Your Immune System and How to Defend Against Them.

“A practical, science-based guide to weight health. Ashley translates complex hormone science into clear, actionable steps — no gimmicks, just results.”
— JJ Virgin, CNS, CHFS, New York Times bestselling author.

“With humor, precision, and years of experience, Ashley Koff, RD, serves as your detective, pointing out clues to explain the challenge of healthy, sustained weight loss and providing a clear road map for success!”
— Victoria Maizes, MD, Founding Executive Director, Andrew Weil Center for Integrative Medicine.

“Ashley Koff, RD, is my go-to expert on nutrition and weight health in corporate wellness. In Your Best Shot, she delivers a science-based, easy-to-follow, and compassionate approach to optimizing the body’s natural hormone intelligence. You can use her program whether or not you use GLP-1 medications. Ashley helps us shift from chasing quick fixes to building sustainable, hormone-smart habits that truly support mental focus, energy, and well-being. Every leader and organization serious about employee health should have this book on their shelf.”
— Dr. Romie Mushtaq, Neurologist, Chief Wellness Officer, Author of The Busy Brain Cure.

“Your Best Shot is a revolutionary personalized approach to weight management. Ashley Koff, RD, who is recognized as a leading nutrition innovator, has delivered her unique skills and clinical experience in this important book that provides a successful approach to weight loss in the age of GLP-1 medications. This book is a must-read for anyone trying to make sense of how to manage their weight.
— Jeffrey Bland, PhD, President, Big Bold Health

“In Your Best Shot, Ashley Koff RD gives you the manual and rationale for conducting your n:1 experiment to optimize your metabolic hormones for better overall health. It’s a valuable tool for patients and practitioners alike.”
— Sara Szal, MD, Bestselling Author of Women, Food, and Hormones.

“With the author’s introduction from a highly personal perspective and her patient vignettes, Your Best Shot is a tour de force that anyone who cares about their health (most people?) should read. It is also a must-read for the weight loss community, the body image community, the diabetes community, and the nutrition community. The author translates complex biology and clinical science with a clarity that is hard to rival.”
– Jed W. Fahey, ScD, Nutritional Biochemist, Johns Hopkins University Schools of Medicine and Public Health.

“Working with Ashley has been a joy! I love her passion and her perspective on weight health as the gateway to whole-person health. She’s a gifted communicator. Full of energy, fun, and clarity, while also taking the science and clinical responsibility of GLP-1 therapy seriously… shot or not! What sets her apart is how well she helps clinicians navigate the complexity of GLP-1 options and confidently communicate those choices to patients. Your Best Shot reflects who she is: approachable, grounded, and focused on helping people get real, sustainable results for every patient.”
-Nate Freeman, VP Science & Innovation, Ortho Molecular Products

“Ashley Koff’s Your Best Shot is the antidote to health overwhelm. Instead of one-size-fits-all advice or quick fixes, Koff empowers readers to build a truly personalized plan for long-term metabolic and hormonal balance—whether you’re on a GLP-1 medication or not. Practical, science-backed, and refreshingly human, this book helps you understand your body’s “ecosystem” and make better—not perfect—choices that last.
– Colleen Cutliffe, Co-founder, CEO of Pendulum Therapeutics.

Real People. Real Results. Personal experiences from individuals whose lives have been transformed by Ashley’s guidance and the principles inside Your Best Shot.

“Ashley is the most knowledgeable nutritionist that I have ever worked with. She really cares about her clients and is able to work around food intolerances and address different personal nutritional needs. It seems like there is nothing she doesn’t know about nutrition.”
— Emily Deschanel, Actress, Producer, Mom.

“For my entire life, I had dealt with unpredictable, intense chronic gut pain. I met Ashley 15 years ago, and she opened my eyes to new way of eating and caring for my overall body. Since then, the pain has been eliminated, and Ashley has remained my north star for guidance. Her insights have been nothing short of a miracle transformation in my life.”
– Todd Lieberman, film producer.

“Ashley truly listened to me and asked all the right questions to get me to give her the right info about my diet, medications, etc.  For the first time, someone had my total health in mind.  She got me on the right supplements to address my gut and within FOUR DAYS, I was back to normal gut health.  I have been so happy working with Ashley that I continue to do so and I loop her into all kinds of discussions regarding all aspects of my health.”
– Lisa A. Fitzmaurice, client

“Ashley’s star shines within the cosmos of patient-centered, whole-body wellness. Her ideas and modalities work! Please read this book. As I have experienced, Ashley will get you on track and reshape your life.”
— David Gardner, client

“I’ve always been a healthy eater and athlete, but as I got older, I found that I’d plateaued at a certain weight. Based on my personal story and family history, Ashley Koff, RD helped me fine-tune my diet and lifestyle. After a period of months under her guidance, my hair, skin, and fitness had never been better. Over 10 years later, I still practice the fundamentals Ashley taught me to be my best, healthiest self!”
– Courtney Knapp, client

“Ashley has changed my life. I had been having serious gut health issues for over a year, and had been meticulously taking out every food and dietary supplement from my life to see if each one was the culprit, only to find that there was no culprit. Feeling totally overwhelmed and completely hopeless, not to mention way too thin because I was not getting the nutrients from my food, I turned to Ashley for help.”
– BNP Client

Ready to Take Your Best Shot?